People

Abdallah M Abdallah

Research Scientists

Research Interests

I am focusing on comparative genomics of environmental mycobacteria and on mycobacteria-host interactions.  My main research interests include molecular genetics and genomics of mycobacteria.

Selected Publications

  • Ho YS, Adroub SA, Abadi M, Al Alwan B, Alkhateeb R, Gao G, Ragab A, Ali S, van Soolingen D, Bitter W, Pain A, Abdallah AM. Complete genome sequence of Mycobacterium vaccae type strain ATCC 25954. J Bacteriol. 2012 Nov;194(22):6339-40.
  • Ho YS, Adroub SA, Aleisa F, Mahmood H, Othoum G, Rashid F, Zaher M, Ali S, Bitter W, Pain A, Abdallah AM. Complete genome sequence of Mycobacterium fortuitum subsp. fortuitum type strain DSM46621. J Bacteriol. 2012 Nov;194(22):6337-8.
  • Mycobacterium phlei type strain RIVM601174.J Bacteriol. 2012 Jun;194(12):3284-5.
  • Mycobacterium xenopi type strain RIVM700367.J Bacteriol. 2012 Jun;194(12):3282-3.
  • Houb
  • en D1, Demangel C, van Ingen J, Perez J, Baldeón L, Abdallah AM, et al., ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cell Microbiol. 2012 Aug;14(8):1287-98.
  • Weerdenb
  • urg EM, Abdallah AM, Mitra S, de Punder K, van der Wel NN, Bird S, Appelmelk BJ, Bitter W, van der Sar AM. ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. Cell Microbiol. 2012 May;14(5):728-39.
  • Abda
  • llah AM, Bestebroer J, Savage ND, de Punder K, van Zon M, Wilson L, Korbee CJ, van der Sar AM, Ottenhoff TH, van der Wel NN, Bitter W, Peters PJ. Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation. J Immunol. 2011 Nov 1;187(9):4744-53
  • .
  • D
  • aleke MH, Cascioferro A, de Punder K, Ummels R, Abdallah AM, van der Wel N, Peters PJ, Luirink J, Manganelli R, Bitter W. Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway. J Biol Chem. 2011 May 27;286(21):19024-3
  • 4.
  • Ab
  • dallah AM, Verboom T, Weerdenburg EM, Gey van Pittius NC, Mahasha PW, Jiménez C, Parra M, Cadieux N, Brennan MJ, Appelmelk BJ, Bitter W. PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5. Mol Microbiol. 2009 Aug;73(3):329-
  • 40.
  • A
  • bdallah AM, Savage ND, van Zon M, Wilson L, Vandenbroucke-Grauls CM, van der Wel NN, Ottenhoff TH, Bitter W. The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J Immunol. 2008 Nov 15;181(10):7166
  • -75.
  • Abdallah AM, Gey van Pittius NC, Champion PA, Cox J, Luirink J, Vandenbroucke-Grauls CM, Appelmelk BJ, Bitter W. Type VII secretion--mycobacteria show the way. Nat Rev Microbiol. 2007 Nov;5(11):883
  • -91.
  • Abdal
  • l
  • a
  • h AM
  • , Verboom T, Hannes F, Safi M, Strong M, Eisenberg D, Musters RJ, Vandenbroucke-Grauls CM, Appelmelk BJ, Luirink J, Bitter W. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol Microbiol. 2006 Nov;62(3):667-79.
  • v
  • an der Sar AM, Abdallah AM, Sparrius M, Reinders E, Vandenbroucke-Grauls CM, Bitter W. Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. Infect Immun. 2004 Nov;72(11):6306-12.

Education

Ph.D. in Molecular Microbiology, VU University Amsterdam, The Netherlands, 2007

M.S. in Biomedical Sciences, Leiden University, The Netherlands, 2003