Host-pathogen interactions

Multi‑omics approaches to identify candidate biomarkers and drug targets for pathogenic organisms

Post-transcriptional gene regulation across parasitic diseases and therapeutics targets

• Gornik, S. G., Flores, V., Reinhardt, F., Erber, L., Douvropoulou, O., Lassadi, I., Einarsson, E., Morl, M., Git, A., Stadler, P., Pain, A., & Waller, R. F. (2022). Mitochondrial genomes in Perkinsus decode conserved frameshifts in all genes. Molecular Biology and Evolution 39, 10, October (2022). https://doi.org/10.1093/molbev/msac191
• Mourier, Shuaib, M., Hala, S., Mfarrej, S., Alofi, F., Naeem, R., Alsomali, A., Jorgensen, D., Subudhi, A. K., Ben Rached, F., Guan, Q., Salunke, R. P., Ooi, A., Esau, L., Douvropoulou, O., Nugmanova, R., Perumal, S., Zhang, H., Rajan, I., … Pain, A. (2022). SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load. Nat Commun 13, 601 (2022). https://doi.org/10.1038/S41467-022-28287-8
• Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzmán-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Júnior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fátima Ferreira-da-Cruz, Ricardo Lourenço de Oliveira, Stefan T. Arold, Daniel C. Jeffares, Patrícia Brasil, Cristiana Ferreira Alves de Brito, Richard Culleton, Cláudio Tadeu Daniel-Ribeiro, Arnab Pain. The genome of the zoonotic malaria parasite reveals adaptations to host-switching.  BMC Biol 19, 219 (2021). https://doi.org/10.1186/s12915-021-01139-5
• Ramaprasad, A., Klaus, S., Douvropoulou, O., Culleton, R. \& Pain, A. Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites. BMC Biol 19, 69 (2021). https://doi.org/10.1186/s12915-021-00995-5
• Meenakshi A Belekar, Tejashree Hingamire, Alok Tanala Patra, Olga Douvropoulou, Amit Kumar Subudhi, Raeece Naeem, Arnab Pain, Rajesh Chandramohandas, Dhanasekaran Shanmugam. Forward chemical-genetic screening on T. gondii gives an insight into molecular mechanism of delayed death phenotype using Pathogen Box molecules. (under preparation)

PhD in Biosciences, KAUST