Tobias Mourier

Consultant Research Scientists

Consultant Research Scientist

Current

Social Profile:

Research Interests

​My current research involves the computational analysis of transcriptome data from apicomplexan parasites. Of special interest is the regulation of splicing and transcriptional activity of the transposable elements present in a few apicomplexan genomes.

Selected Publications

  • AK Subudhi, JL Green, R Satyam, RP Salunke, T Lenz, M Shuaib, et al., DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages, Nature Microbiology, 1-16, 2023, 10.1038/s41564-023-01497-6
  • M Shuaib, S Adroub, T Mourier, S Mfarrej, H Zhang, L Esau, A Alsomali, et al., Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity, Genome Medicine, 15 (1), 54, 2023, 10.1186/s13073-023-01208-0
  • M Haidar, S Tajeri, L Momeux, T Mourier, F Ben-Rached, S Mfarrej, et al., miR-34c-3p Regulates Protein Kinase A Activity Independent of cAMP by Dicing prkar2b Transcripts in Theileria annulata-Infected Leukocytes, Msphere, 8 (2), e00526-22, 2023, 10.1128/msphere.00526-22
  • AN Alshukairi, Y Aldabbagh, SA Adroub, T Mourier, KY Abumelha, et al., Outcome of Transplant Recipients Infected with Omicron BA. 1 and BA. 2: A Single-Center Retrospective Study in Saudi Arabia,Journal of Epidemiology and Global Health, 13 (1), 47-54, 2023, 10.1007/s44197-023-00084-6
  • S Tajeri, L Momeux, B Saintpierre, S Mfarrej, A Chapple, T Mourier, et al., Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion, Scientific Reports, 12 (1), 12710, 2022, 10.1038/s41598-022-15518-7
  • T Mourier, M Shuaib, S Hala, S Mfarrej, F Alofi, R Naeem, A Alsomali, et al., SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load, Nature communications, 13 (1), 601, 2022, 10.1038/s41467-022-28287-8
  • T Mourier, DAM de Alvarenga, A Kaushik, A de Pina-Costa, et al., The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching, BMC biology, 19, 1-17, 2021, 10.1186/s12915-021-01139-5
  • C Cao, J He, L Mak, D Perera, D Kwok, J Wang, M Li, T Mourier, et al., Reconstruction of microbial haplotypes by integration of statistical and physical linkage in scaffolding, Molecular biology and evolution, 38 (6), 2660-2672, 2021, 10.1093/molbev/msab037
  • T Mourier, M Sadykov, MJ Carr, G Gonzalez, WW Hall, A Pain, Host-directed editing of the SARS-CoV-2 genome, Biochemical and biophysical research communications, 538, 35-39, 2021, 10.1016/j.bbrc.2020.10.092
  • M Sadykov, T Mourier, Q Guan, A Pain, Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction, Journal of Molecular Cell Biology, 13 (3), 225-227, 2021, 10.1101/2020.06.19.161687
  • T Mourier, M Shuaib, S Hala, S Mfarrej, F Alofi, R Naeem, A Alsomali, et al., RNA-Seq HEK293T cells transfected with plasmids expressing SARS-CoV-2 Nucleocapsid protein, NCBI, , 2021
  • K Barylyuk, L Koreny, H Ke, S Butterworth, OM Crook, I Lassadi, V Gupta, et al., A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions, Cell host & microbe, 28 (5), 752-766. e9, 2020, 10.1016/j.chom.2020.09.011
  • AC Balestra, M Zeeshan, E Rea, C Pasquarello, L Brusini, T Mourier, et al., A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission, Elife, 9, e56474, 2020, 10.7554/eLife.56474
  • M Sadykov, T Mourier, Q Guan, A Pain, Cytosine deamination in SARS-CoV-2 leads to progressive CpG depletion., Cold Spring Harbor Laboratory, 2020
  • K Barylyuk, L Koreny, H Ke, S Butterworth, OM Crook, I Lassadi, V Gupta, et al., A subcellular atlas of Toxoplasma reveals the functional context of the proteome, Biorxiv, 2020.04. 23.057125, 2020
  • C Cao, J He, L Mak, D Perera, D Kwok, J Wang, M Li, T Mourier, et al., De novo reconstruction of microbial haplotypes by integrating statistical and physical linkage, Cold Spring Harbor Laboratory, 2020
  • T MOURIER, AMA Denise, A KAUSHIK, PC Anielle, JGV Francisco, et al., The Genome of the Zoonotic Malaria Parasite Plasmodium simium Reveals Adaptions to Host-switching, Journal of Integrated Field Science, 17, 34-34, 2020
  • M Zeeshan, F Shilliday, T Liu, S Abel, T Mourier, DJP Ferguson, E Rea, et al., Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission, PLoS pathogens, 15 (10), e1008048, 2019, 10.1371/journal.ppat.1008048
  • M Asplund, KR Kjartansdóttir, S Mollerup, L Vinner, H Fridholm, et al., Contaminating viral sequences in high-throughput sequencing viromics: a linkage study of 700 sequencing libraries, Clinical Microbiology and Infection, 25 (10), 1277-1285, 2019, 10.1016/j.cmi.2019.04.028

Education

  • ​Ph.D. in Biology (2003), University of Copenhagen, Denmark

Research Interests Keywords

Genomics Biological networks and interactions Bioinformatics