Impact of SARS-CoV-2 203K/204R Mutations on COVID-19
KR patients showed elevated proinflammatory cytokines, chemokines, ISGs, and neutrophil levels, indicating a hyper-inflammatory response compared to RG patients.
Evolutionary Analysis Identifies Golgi Pathway in Apicomplexans
The organelle paralogy hypothesis (OPH) suggests that new organelles evolve when membrane-trafficking components duplicate and change together. In Apicomplexa, we found 18 such duplicated components, some linked to new organelles. We also discovered a new pathway in these parasites that helps deliver proteins crucial for invasion, supporting the OPH theory.
PfAP2-P regulates parasite pathogenesis during IDC
PfAP2-P is a crucial transcription factor in Plasmodium falciparum, regulating trophozoite development, var genes, and parasite egress.
Hypervirulent & Resistant K. pneumoniae CC14 clone found in hospitals
Dominant CC14 strains, especially ST2096, expanded in hospitals, acquiring antibiotic resistance and high virulence, linked to sepsis and mortality.
Welcome to PGL
At the Pathogen Genomics Laboratory, we bridge the gap between massive biological data and life-saving medical breakthroughs. We don’t just study pathogens; we dismantle them at the molecular level to understand how they thrive, evolve, and invade.
Using high-throughput DNA and RNA sequencing coupled with advanced bioinformatics, we expose the genomic blueprints of the viruses, bacteria, and parasites that threaten global human and animal health in the Kingdom and beyond.
From Data to Defense.
By mastering the genomics of these microbes, we are paving the way for the next generation of detection, surveillance, and intervention strategies.